Abstract

LIPID PEROXIDATION, BLOOD PRESSURE AND LIPID PROFILE STATUS OF DIABETIC ISCHAEMIC STROKE SUBJECTS

Wali U*., Saidu Y., Balarabe S.A., Suleiman A. I., Sahabi D. M. and Bilbis L. S.

ABSTRACT

Acute Ischaemic Stroke (AIS) is characterized by elevated level of oxidative stress indices, declined antioxidant defences and dyslipidaemia. Increased oxidative stress is thought to play a role in the development of AIS and its attendant complications. In the current study, fasting blood glucose, malondialdehyde, blood pressure, total cholesterol, triacylglycerol, very low density lipoprotein cholestreol, low density lipoprotein cholesterol, high density lipoprotein cholesterol and atherogenic index levels were estimated in 37 diabetic ischaemic stroke (DIS) subjects admitted in Neuro Medical ward of Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria and the results compared with 42 non-diabetic ischaemic stroke (NDIS) subjects of comparable age and social status. The results suggested significant (P<0.05) increase levels of FBS, MDA, and BP in diabetic ischaemic stroke subjects compared with non-diabetic ischaemic stroke subjects. It also revealed non-significant (P>0.05) increase levels of TC, TAG, HDL-C, LDL-C, and VLDL-C and decreased AIX in DIS compared with NDIS subjects. The findings suggest that diabetic ischaemic stroke subjects had more oxidative stress and dyslipidaemia associated with acute ischaemic stroke.

Keywords: Acute ischaemic stroke, lipid profile and oxidative stress.