Photo Gallery



News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.



Xinwei Zhou, Chang Liu, Xinru Zhao, Xiaohong Wang*


Building a three-dimensional (3D) tissue model in vitro instead of animal models to test drug sensitivity has been an inevitable trend in drug research and development for it is less expensive, less time consuming, and more tightly controlled. In this article, a 3D liver tumor model consisting of HepG2 cells and sodium alginate/gelatin/fibrinogen hydrogel was created using a cell 3D bioprinter developed in Tsinghua University our own group. The subsequent scanning electron microscope observation and acridine orange/propidium iodide staining results indicated that HepG2 cells loaded in the alginate/gelatin/fibrinogen hydrogel grew well with high cell livability. Cell Count Kit-8, alpha-fetoprotein and half maximal inhibitory measurements demonstrated and verified that under the treatment of different anti-cancer drugs, such as 5-Fluorouracil, mitomycin and their combination, significant differences between the HepG2 cell behaviors in the 3D and 2D conditions were existed. The 3D liver tumor model is a promising application for in vitro drug screening.

Keywords: 3D cell bioprinting; drug screening; liver tumor model; HepG2 cells; 2D cell culture.

[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More