Abstract

ATTENUATION AND IMPROVEMENT, TOXICITY AND EFFICACY OF VANADIUM DERIVATIVES

Yi Liu, Zhiming Fu, Yue Song, Jiyong Yan, Zhibiao Di, Chunchao Han,*

ABSTRACT

Oral administration of inorganic vanadium salts have shown antidiabetic activity. However, the toxicity associated with vanadium limits its role as a therapeutic agent for diabetic treatment. The objective of this article is briefly to review studies on chemical approaches to reduce vanadium-associated toxicity and maintain its anti-diabetic effects meanwhile. We also provide some insights into the potential therapeutic measures of the anti-diabetic vanadium actions.

Keywords: vanadium; hypoglycemic activity; diabetic; toxicity