Abstract

PHARMGEONETIC EFFECT ON PLASMA CONCENTRATION OF TAMOXIFEN THROUGH HPLC IN FEMALE SUBJECTS OF PAKISTAN

Kiran Shahbaz* and Ijaz Javed

ABSTRACT

The pharmgeonetic and pharmenzymonetic factors alter plasma concentration of a drug achieved after the same dosage regimen in various individuals. Breast cancer being second most killing disease holds tamoxifen as a treatment of choice for years for woman. Its plasma concentration determines therapeutic output for that eight healthy female volunteers were selected from Pakistan region and single dose 20mg of Tamoxifen was given. After collection of blood samples at known intervals, plasma concentration was determined by high performance liquid chromatography. The maximum plasma concentration was 32.54±0.44 ng/mL at time 6 hours after administration. Mean ± SE initial tamoxifen concentration was 4.8 ± 0.41 ng/mL and at 24 hours it was recorded as 7.4 ± 2.06 ng/mL respectively. The concentration obtained was lesser than literature values proving geographical region dependent decrease altering therapeutic outcome and therapeutic drug monitoring is essential for breast cancer patients in short and for every ailment in long term.

Keywords: Tamoxifen Plasma Concentration, HPLC for Tamoxifen, Breast Cancer Medicine, Pharmenzymonetics, Pharmgeonetics.