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Abstract

ROLE OF ASSAM BORA RICE STARCH AS DIRECT COMPRESSIBLE TABLET EXCIPIENT

Prakash Rajak*, Biman Bhuyan

Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh -786004, Assam, India.

ABSTRACT

Purpose: The aim of this study was to evaluate the possible use of Assam Bora rice starch as directly compressible tablet excipient in comparison to pregelatinized starch. Methods: The starch was extracted from the rice, evaluated for relevant properties and used as direct compression tablet excipient in Ketotifen tablets. The tablets were evaluated for tensile strength, friability, drug content, disintegration and dissolution profiles. Ketotifen tablets containing pregelatinized starch as direct compression tablet excipient were produced and assessed comparatively. Result: The tablets were evaluated for tensile strength, friability, drug content, disintegration and dissolution profiles. Results obtained indicate that Assam Bora rice starch performed as good as pregelatinized starch as a direct compression tablet excipient to Ketotifen tablets. Conclusion: The tablet properties show that Assam Bora rice starch is a useful product for preparation of tablets by direct compression as compared to pregelatinized starch.

Keywords: Assam Bora rice, Direct compression, Pregelatinized starch, Ketotifen


[Full Text Article]

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