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Abstract

MICROWAVE-ASSISTED SYNTHESIS OF SOME PYRAZOLE DERIVATIVES OF PYRAZOLO [3,4-C]PYRAZOLES AND EVALUATION OF THEIR ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY

Deepak Swarnkar*, Rakshit Ameta and Ritu Vyas

ABSTRACT

The synthesis of two series of substituted pyrazole derivatives (4)-(7) and (10)-(13) has been achieved by reaction of chalcones of pyrozolone (3) and (9) with hydrazine hydrate, phenyl hydrazine, semicarbezide and thiosemicarbezide under microwave irradiation in various reaction conditions. The structures of the synthesized compounds were assigned on the basis of IR and 1H NMR analysis. These targeted compounds have been screened for their antibacterial and antifungal activities using Broth dilution method and compared with standard drug ampicillin for antibacterial activity and griseofulvin for antifungal activity. Compounds (4), (5), (10), (11) and (12) have shown higher antibacterial activities while (4), (5), (6), (7), (10), (11) and (12) have shown higher antifungal activities.

Keywords: Ethylacetoacetate, Chalcones, Pyrazolone, Antibacterial activity, Antifungal activity.


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