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Abstract

FORMULATION AND EVALUATION OF IMMEDIATE RELEASE OF IRBESARTAN TABLETS

D. Savitha*, A. Sajeeda, Pooja Agarwal, S. Rani, Manasa Padma M., V. Shalini

ABSTRACT

Irbesartan is water insoluble oral antihypertensive agent, with problems of variable bioavailability and bioequivalence related to its water insolubility. Irbesartan is a highly potent, long-acting and Selective Angiotensin II Type I (AT) receptor blocker. It is administered orally as the inactive prodrug Irbesartan which is rapidly and completely converted to Irbesartan during gastrointestinal absorption. Irbesartan should be administrated orally once or twice daily for a total daily dosage of 4 to 32 mg. In this investigation rapid disintegrating tablet were prepared by using super disintegrating agent; crospovidon, crosscaremellose sodium, sodium starch glycolate in concentration 3%, 4%, 5%. Sweeteners and flavors were used to enhance the organoleptic properties of tablet. Tablets were prepared by direct compression technique. Prepared tablets were evaluated for thickness, uniformity of weight, hardness, friability, wetting time, in-vitro disintegration time, drug content and in vitro drug release. Disintegration time and drug release were taken as the basis to optimize the rapidly disintegrating tablet.

Keywords: Rapid disintegrating tablet, superdisintegrants, Irbesartan, crospovidon, Crosscarmellose sodium, sodium starch glycolate.


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