Abstract

SYNTHESIS AND CHARACTERIZATION OF NOVEL 3-PHENYL- 2-THIOQUINOZOLINE 4-3(H)-ONE MANNICH BASES

Venkateshan N.*, Rajapandi R. And Lavakumar V.

ABSTRACT

The role played by organic chemistry in the pharmaceutical industry continues to be one of the main drivers in the drug discovery process.Quinazoline is a heterocyclic compound made up of two fused six-membered simple aromatic rings, a benzene ring and a pyrimidine ring. Its chemical formula is C8H6N2. Quinazoline is yellow solid. It is isomeric with other naphthyridines including quinoxaline, phthalazine and cinnoline. Derivatives of quinazoline are called quinazolines. Many derivatives of quinazoline system known so far, keto-quinazolines also called as quinazolinones, are the most important compounds. Depending upon the position of the keto or oxo group, these compounds may be classified into two types: 2-(1H) quinazolinones (or) 1,2-dihydro-2-oxo quinazolines and 4(3H)-quinazolines or 3,4-dihydro-oxoquinazolines. There is no report of degradation of quinazolinone by simple chemical oxidation. On the basis of these considerations, and in continuation to the previous efforts of our laboratory team in the area of Quinazoline derivatives. The 3-Phenyl- 2-Thioquinozoline 4-3(h) One Were Prepared By Using Carbondisulphide, Aniline, Anthranillic acid, Potassium hydroxide, Methanol and Ethanol. The 3-Phenyl- 2-Thioquinozoline 4-3(h)-One Mannich Bases Were Prepared By Formaldehyde and Amine (Piperazine, Phenyl Hydrazine and sulphanilamide) The newly synthesized compounds I, II and III was yielded satisfactorily. Appearances, percentage of yield, melting point of the compounds were given in the appropriate synthetic procedure. The completion of the chemical reaction was monitored by TLC. All newly synthesized Compounds were confirmed by means of their IR and 1H NMR.

Keywords: It is isomeric with other naphthyridines including quinoxaline, phthalazine and cinnoline. Derivatives of quinazoline are called quinazolines.