WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

GLUTATHIONE-S-TRANSFERASE OF HAEMONCHUS CONTORTUS - A VULNERABLE TARGET FOR ALLIUM SATIVUM AND ANDROGRAPHIS PANICULATA

L. Veerakumari and N. Chitra*

ABSTRACT

Haemonchosis has been identified as major gastrointestinal parasitic disease in livestock caused by Haemonchus contortus. It is an important bloodsucking parasite of ovines and causes an insidious drain on production and high mortality in all classes of livestock. Drug resistance necessiated the exploration of alternative control methods. Therefore, there is a need for developing cheaper, less toxic and ecofriendly novel drugs. Indigenous medicinal plants offer an important alternative source. Glutathione-S-transferase (GST) are major metabolic enzymes and may play an important role in the parasite’s survival. GST’s are able to scavenge the products of lipid peroxidation and to metabolize toxic products, including anthelmintics. The effect of ethanol extract of Allium sativum (AsEE) and chloroform extract of Andrographis paniculata (ApCE) on GST activity of the nematode H. contortus was studied. The worms were exposed to various sublethal concentrations of AsEE and ApCE for 2, 4 and 8h. GST was assayed in control and drug-treated worms. Maximum inhibition of GST activity was observed at 0.5 mg/ml of AsEE and ApCE after 8 h of exposure. Inhibition of GST activity was dose and time dependent. Reduction in GST leads to accumulation of toxic metabolites which ultimately kill the parasites. The present study thus enlightened the anthelmintic effect of AsEE and ApCE, which can be used to combat nematode infection in livestock.

Keywords: Allium sativum, Andrographis paniculata, Haemonchus contortus and Glutathione-S-transferase.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More