Abstract

THERAPEUTIC POTENTIAL OF TRIMETAZIDINE ON ANTI – INFLAMMATORY ACTIVITY ON RATS

Puja Kumari*, Vipin Kumar Soni, Vishweshar Bhagat, Vinod Kumar and Jagdish Rathi

ABSTRACT

The present study was designed to elucidate the effects of Trimetazidine and their administered drug in formalin-induced paw edema model inflammatory model. Male Lewis rat (divided into 4 groups with 6 animals each) were treated with Group1-control, Group 2-Negative control, Group 3- Diclofenac 50 mg/kg, Group 4- Trimetazidine 25 mg/kg. On the 28th day, evaluate various behavioral tests such as Hind paw volume and edema, body weight, arthritis scale and locomotor activity. Data was analyzed using One way ANOVA followed by Dunnette‟s test (p<0.05) was considered statistical significant. Arthritic control group significantly (p< 0.05) impaired Hind paw volume and edema, body weight and locomotor activity as compared as compare to negative and therapeutic. Trimetazidine (25mg/kg; orally) significantly (p< 0.05) reduced hind paw volume and edema, improved body weight and improved locomotor activity. Further, trimetazidine (25 mg/kg) significantly (p < 0.05) potentiated the anti- inflammatory as compared to their effects alone. The present study to investigate the trimetazidine has as antioxidant, anti-inflammatory activity and energy homeostasis hence a could be a promising strategy to treat inflammation.

Keywords: anti-arthritis, locomotors activity, trimetazidine, antioxidant, antiinflammatory.