Abstract

PRELIMINARYSTUDY ON NOOTROPICEFFECT OF VANDA TESSELATA ROOTS

Patel Shivabhai K., Petricia Regina Irene, Dr. N. Venkat Rao, G. Ramu*

ABSTRACT

The research work deals with the screening of ethanolic extract of Vanda tessellata(AERVT) roots using Elevated plus maze (EPM), Scopolamine and Diazepam induced models in mice. Piracetam was used as reference for the study. The Vanda tessellata root is known to contain saponins, glycosides, alkaloids, steroids and tannins in phytochemical screening. Since root of Vanda tessellata is used as folk medicine for diseases of nervous system, we made an attempt to study for nootropic activity.When this extract is subjected for LD50 studies it did not produced any abnormal behaviour or mortality even at the dose level of 2000 mg/Kg body weight in mice. Three different doses100 mg/kg, 200 mg/kg and 400 mg/kg doses were selected for the present study with respect to maximum dose tested for LD50 study.In this study with the EPM model, Diazepam and Scopolamine induced amnesic models, the transfer latency is significantly reduced with 200 mg/kg and 400 mg/kg doses of AERVT. The result of the study confirmed that the nootropic effect of ethanolic extract was due to several phytoconstituents like saponins, glycosides, alkaloids which were already reported for their nootropic activity.

Keywords: Vanda tessellataRoxb, Alcoholic extract, Nootropic, Piracetam, EPM, Scopolamine, Diazepam.