Abstract

MEDICINAL PRODRUGS APPROACHES FOR COLON TARGETED RELEASE: A REVIEW

*Singh Deepak, Kumar Anoop and Shrivastava A. K.

ABSTRACT

In the conventional therapeutic system the oral delivery of drugs are most easily accepted route of administration but gastrointestinal tract (GIT) may create several hindrance to delivery of therapeutic drugs at specific site like colon hence colon targeted drugs delivery approaches now a days widely accepted for treatment if disorder associated with colon like IBDs, Chron‟s disease, ulcerative colitis, colorectal cancer and amoebiasis. Numerous prodrugs have been designed and developed since then to overcome pharmaceutical and pharmacokinetic barriers (degradation, release and absorption in the upper portion of the GI tract) and then to be ensured controlled release in the proximal colon in clinical drug application. This strategy increases the selectivity of drugs for intended target and there is a lower chance for attack on healthy cells with reduce side effect.

Keywords: Prodrugs, IBDs, CTDDS, Medicinal approach.