Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.

Abstract

MODIFIED FENUGREEK GUM FOR SOLUBILITY AND DISSOLUTION RATE ENHANCEMENT OF SIMVASTATIN

Ajay Kumar Sav*1, Ritesh Fule1, Kailas Moravkar1, Purnima Dhanraj Amin1

1Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology,N. P. Marg, Matunga, Mumbai 400019, India.

ABSTRACT

Simvastatin is a hypolipidemic BCS class II drug and has poor bioavailability due to low aqueous solubility. Solid dispersion is the one of the most promising method for improving the water solubility and therefore the drug bioavailability. In this study, solid dispersion of Simvastatin was prepared using lab synthesized hydrophilic surface active polymer octenyl succinate fenugreek gum as a carrier by cosolvent precipitation method. Different batches of solid dispersion were prepared in varying drug polymer ratio. Prepared solid dispersions were evaluated for solubility and dissolution rate. It was found that solid dispersion prepared from drug polymer 1:0.1 weight ratio showed threefold increase in dissolution rate and solubility was also improved several fold in dissolving medium. Solid dispersion was characterized for physicochemical property by differential scanning calorimetry, scanning electron microscopy, FTIR and particle size distribution. The compilations of these results revealed that increase in surface wet ability by hydrophilic carrier responsible for the dissolution rate enhancement.

Keywords: Simvastatin, fenugreek gum, solid dispersion, dissolution rate.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More