Abstract

AN ANTIHISTAMINIC ACTIVITY OF VITAMIN D IN EXPERIMENTAL MODELS

Ashok D. Agrawal, Kiranj K. Chaudagar, Vasu Appanna, Anita A. Mehta*

ABSTRACT

Background: The inverse correlation exists between plasma vitamin D level and development of asthma whereas the direct correlation exists between occurrence of asthma and histamine level. Therefore, we aimed to evaluate anti-histaminic activity of vitamin D in experimental models. Materials and Methods: The histaminic actions modulating role of vitamin D was assessed using histamine induced bronchospasm in guinea pigs, clonidine induced rat mast cell degranulation and haloperidol induced catalepsy in mice. Results: The vitamin D treatment showed significant (p<0.001) increased in histamine induced proconvulsive time in guinea pigs, inhibited clonidine induced rat mast cell degranulation and attenuated haloperidol-induced catalepsy in mice. Conclusion: The current study revealed that vitamin D possesses antihistaminic activity by inhibiting H1 receptor action and histaminerelease from the cells.

Keywords: Vitamin D, histamine, asthma.