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Abstract

IN VITRO ANTI-INFLAMMATORY ACTIVITY OF CARMONA RETUSA (VAHL.)

Chandrappa CP1, Govindappa M1*, Anil Kumar NV2 and Channabasava R1

1Department of Biotechnology, Shridevi Institute of Engineering and Technology, Tumkur572106, Karnataka, India.

2Department of Chemistry, Manipal Institute of Technology, Manipal University, Karnataka,India.

ABSTRACT

The anti-inflammatory activity of ethanol extract of stem of Carmona retusa was investigated for in-vitro anti-inflammatory activity by human red blood cell membrane stabilization method, heat induced hemolysis and proteinase inhibitory activity. The anti-inflammatory activity of Carmona retusa found maximum in human red blood cell membrane stabilization method, heat induced hemolysis and proteinase inhibitory activity as 55.72%, 56.37% and 61.75% respectively at 400μg/ml concentration. Minimum anti-inflammatory activity has shown at 50μg/ml concentration as 28.92μg/ml, 15.43μg/ml and 11.33μg/ml in the methods used. IC50 values were calculated for all the methods and found to 30.31, 19.62 and14.53μg/ml for human red blood cell membrane stabilization method, heat induced hemolysis and proteinase inhibitory activity respectively. The anti-inflammatory activity of the sample was comparable with that of the standard diclofenac. The results obtained in the present study suggest that Carmona retusa can be a potential source of antiinflammatory agents.

Keywords: Carmona retusa, anti-inflammatory activity, HRBC, IC50.


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