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Abstract

VALIDATION OF UV SPECTROSCOPIC METHOD OF ANALYSIS FOR ASSAY AND DISSOLUTION OF ACECLOFENAC TABLET

*Kaushik Rasiklal Valambhia

P.O.Box 38203, Dar-es-Salaam United Republic of Tanzania.

ABSTRACT

Aceclofenac is a non steroidal anti-inflammatory drug with good analgesic and anti-rheumatic properties. Various methods for analysis of the same are available but are time consuming and expensive due to solvents used .Here I have developed a new, precise and simple UV spectrophotometric method for estimation of aceclofenac from tablet formulation. The drug obeyed the Beer’s law and showed good correlation. It showed absorption maxima at 276 nm; in methanol for assay and Phosphate buffer pH 6.8 for dissolution. The linearity was observed between 0-120 mcg/ml. The results of analysis were validated by recovery studies. The recovery was more than 99%. The method was found to be very simple. Accurate, precise, economical and robust.

Keywords: Aceclofenac, UV-Vis spectrophotometry Recovery.


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