Abstract

COMBINATION OF ASPIRIN, CLOPIDOGREL BISULPHATE AND ATORVASTATIN CALCIUM BILAYER TABLETS FOR HEART DISEASES

Natarajan R*., Abirami M., Sreekanth K., Sharadhamani G., Ananda Thangadurai S.,

ABSTRACT

Multilayered tablets possess various benefits, like improves its efficacy and safety by controlling the rate, time, and place of release of drugs in the body and the ability to prevent incompatibility between drugs and excipients; and by providing multiple release kinetics mechanisms. The ternary combination is used for atherosclerotic patients suffering from various heart diseases. Clinical trials showed that combination therapy when used in dyslipidaemic patient with coronary heart disease reduced cardiovascular events. Bilayer tablets containing immediate release layer of Aspirin, Clopidogrel Bisulphate and sustained release layer of Atorvastatin Calcium were prepared by dry granulation method and their evaluation were carried out. The formulated tablets (F1, F2 and F3) were compared with marketed capsules containing the same strength of Aspirin, Clopidogrel Bisulphate and Atorvastatin Calcium. The in vitro drug release studies from the developed formulation (F3) showed up to 81.88% up to 12 hours in sustained release manner. Then the similarity factor (f2) was compared the formulation (F3) with Innovator capsules and it was found to be similar.

Keywords: Bi-layer tablets, Ternary combination drug, Heart diseases, Similarity factor, Sustained release.