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Abstract

STUDYING DISPERSION SYSTEMS OF MICONAZOLE NITRATE WITH MANNITOL AND UREA

*Omar H. El-Garhy

Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt.

ABSTRACT

 

Different dispersion systems of miconazole nitrate (MN) with two

water soluble carriers; mannitol and urea, were prepared at drug-carrier

ratios; 2:1, 1:1 and 1:2 w/w, using evaporation and melting methods as

different dispersion methods. The corresponding physical mixtures of

MN with either mannitol or urea were also prepared. Infrared

spectroscopy (IRS) and differential scanning calorimetry (DSC) were

employed to study the physicochemical properties of different prepared

MN-carrier systems. Moreover, in-vitro dissolution studies and

microbiologic assay were performed for characterization and

evaluation of the dissolution behavior and the antimycotic activity of

MN upon its dispersion with mannitol or urea in different systems. The

results of DSC demonstrated that MN-carrier dispersion systems that

prepared by melting method rather than evaporation method display a greater reduction in the

crystallinity of MN. The dissolution behavior of MN from its different prepared dispersion

systems with mannitol or urea was markedly improved comparing by that of MN intact. The

extent of improvement in MN dissolution profile shown by different prepared MN-carrier

dispersion systems was found to be dependent on both the carrier type and the dispersion

method used and is increased as a function of the weight fraction of the investigated carrier

(mannitol or urea). The MN-urea dispersion systems that prepared by melting method at a

drug: carrier ratio 1:2, exhibited better dissolution profile among the other prepared MNcarrier

dispersion systems. The microbiologic assay demonstrated that the aqueous solutions

of MN-carrier systems showed inhibition zones of larger diameter than that of MN intact.

This proved the superiority of the antimycotic activity of MN-carrier systems comparing by

that of MN intact.

Keywords: miconazole nitrate, dispersion, mannitol, urea and dissolution behavior.


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