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Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL 2-ARYL-PYRAN-4-ONES OF 1,8-NAPHTHYRIDIN AND ITS DERIVATIVES

Narendar Atmakuri, Laxminarayana Eppakayala & Thirumala Chary Maringanti*

JNTUH College of Engineering, Nachupally, Karimnagar -505 327 (A.P.) INDIA

Mahatma Gandhi Institute of Technology, Gandipet, Hyderabad-500075 (A.P.) INDIA

ABSTRACT

In the present study, a series of pyranone derivatives of 1,8- naphthyridines (6a-j) were synthesized by condensation of 1-(2- hydroxy-1,8-naphthyridin-3-yl)ethanone (3) and different aromatic aldehydes in ethanolic solution of potassium hydroxide followed by cyclization. Several pyranones have been synthesized and their biological activity (Antimicrobial) investigated using the Ampicillin and Nalidixic acid as standards. The results showed that compound (6d and 6e) shows the higher anti-bacterial activity against gram positive bacteria. The synthesized compounds have been characterized by using Mass, IR and 1H NMR Spectral data together with elemental analysis.

Keywords: 2-Amino-pyridine-3-carbaldehyde, Pyranones ring cyclisation, Antimicrobial activity.


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