Abstract

A REVIEW ON EVALUATION OF ACECLOFENAC NIOSOMES PREPARED BY VARIOUS TECHNIQUES

Shahanas K T, Shahida K V, Shareefa K, Shereehan M, Dr. Prasobh G R*, Dr. Sapna Shrikumar

ABSTRACT

Aceclofenac belongs to non-steroidal anti- inflammatory drug (NSAID) is considered to be the first-line drug in the symptomatic treatment of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. The drug is having narrow therapeutic index, short biological half-life (about 4 h) as well as two third (70-80%) of dose is excreted by renal transport and it makes aceclofenac dosing frequency more than once a day. Niosomes are multilameller vesicular structure of nonionic surfactants, similar to liposomes and are composed of non-ionic surfactant instead of phospholipids which are the components of liposomes. So, niosome or non-ionic surfactant vesicles are now widely studied as an alternative tool to liposome. The present work was to investigate the influence of various preparation techniques on formulation of aceclofenac niosomes by using span and cholesterol by ether injection method,ethanol injection method, sonication method followed by evaluating the parameters such as drug content, entrapment efficiency, particle size, shape and in-vitro drug release and drug release kinetics.

Keywords: Aceclofenac, Niosome, Span, Cholesterol.