WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

CHRONIC ADMINISTRATION OF OLANZAPINE (AN ANTIDEPRESSANT DRUG) LEADS TO IMPAIRED GLUCOSE TOLERANCE IN MICE

Farjana Akther Noor, Mohammad Najmul Hossain and Mohammed Rahmatullah*

ABSTRACT

Background. Olanzapine is a prescription drug used for treatment of psychotic mental disorders. Some reports have indicated diabetes risk following chronic administration of olanzapine. It was of interest to see whether chronic olanzapine treatment leads to impaired glucose tolerance in mice. Methods. Impairment of glucose tolerance was determined through oral glucose tolerance tests (OGTT) in mice. Results. Oral administration of olanzapine to mice at a dose level of 100 mg olanzapine per kg body weight led to statistically significant elevations in blood glucose levels compared to control animals (without olanzapine) following OGTT. After 1, 2 and 4 weeks of olanzapine administration, in oral glucose tolerance tests, the elevations in blood glucose in glucose-challenged mice were, respectively, 119.8, 161.1, and 166.4% compared to control mice (100.0%). Conclusion. Chronic administration of olanzapine can cause impaired glucose tolerance, which can serve as a model to explore other medications to alleviate the problem.

Keywords: Olanzapine, Bangladesh, glucose, OGTT.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More