Abstract

SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF NEW SERIES OF 1, 3, 4 OXADIAZOLE DERIVATIVES

Meenakshi Virmani*

ABSTRACT

After refluxing the mixture of Ethyl (2,4,6-trichlorophenoxy) acetate (1) hydrazine hydrate and absolute ethanol (50 ml) in round bottom flask formed a solid mass of 2,4,6-Trichlorophenoxyacetic acid hydrazide (2). Now Compound 2 and benzoic acid was dissolved in phosphorus oxychloride and refluxed on a heating mantle for 20 hours. It formed a solid mass of 5-(2,4,6-Trichlorophenoxymethyl)-2-substituted phenyl 1,3,4-oxadiazole (3a-q). The structure of these compounds have been established by IR (KBr), 1H NMR (CDCl3) and mass spectroscopy. Compounds (3a-q) have been screened for their anti-inflammatory activities.

Keywords: 1,3,4 oxadiazole, Anti-inflammatory, Standard drug.