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Abstract

FORMULATION AND EVALUATION OF ELEMENTARY OSMOTIC TABLETS OF LAMIVUDINE AND STAVUDINE IN FIXED DOSE COMBINATION

M. Ranga Priya*, Mahendra Babu, N.N.Rajendran

Department of Pharmaceutics & Research, Swamy Vivekanandha College of pharmacy, Elayampalayam-637205, Tamilnadu, India.

ABSTRACT

Most of the conventional drug delivery systems for treating the HIV/AIDS are not much effective as the drugs do not reach the site of action in appropriate concentrations. The objective of present study was concerned with formulation and evaluation of an elementary osmotic tablet of lamivudine and stavudine in fixed dose combination in order to improve efficacy and better patient compliance. Tablets were prepared by wet granulation method using various proportions of polymer PEG 4000 along with Kcl as osmotic agent. The granules were evaluated for angle of repose, bulk density, tapped density and compressibility index, shows satisfactory results. Compressed tablets were evaluated for uniformity of weight, drug content, thickness, friability, hardness and in-vitro dissolution studies. From the in-vitro drug release study the osmotic tablets containing PEG 4000 (20mg) and kcl (40mg) showed 96.06% drug release in 24 hrs which was well controlled in comparison with other conventional preparations. The in-vitro release data from the osmotic tablets showed zero order pattern and the mechanism was non- Fickian. The results also indicate that the osmotic drug delivery system may be successfully utilized for the controlled delivery of Lamivudine and Stavudine up to 24hours.

Keywords: stavudine, lamivudine, osmotic delivery, fixed dose combination,


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