Abstract

SYNTHESIS OF SOME 1,3-BENZOTHIAZOL-2-YL HYDRAZONE DERIVATIVES AS ANTIMICROBIAL AGENTS

Deepali M. Wanode*, S. J. Wadher, Nilesh Y. Jadhav, S. S. Shyale, Manoj B. Kothule

ABSTRACT

A series of 1,3-benzothiazol-2-yl hydrazones were synthesized(IIIa- IIIe) and evaluated for antibacterial activity against two different bacterial species and antifungal activity against one fungal species by disk diffusion method displaying different degree of antimicrobial activity. All the synthesized compounds were in good agreement with spectral data (FTIR, 1H-NMR and mass spectroscopy). In-vitro antibacterial activity was evaluated against two pathogenic bacterial strains, Staphylococcus aureus and Escherichia coli and one fungal strain Aspergillus niger. Synthesized compound IIIa has shown significant antibacterial and antifungal activity compared with standard ciprofloxacin and miconazole at 200μg/ml and 500μg/ml respectively.

Keywords: Antimicrobial, Antibacterial, Antifungal, 1,3-benzothiazol-2-yl hydrazine.