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Abstract

OPTIMIZATION OF NANO-EMULSION FORMULATIONS FOR CERTAIN EMOLLIENT EFFECT

Ahmed A. H. Abdellatif and Heba A. Abou-Taleb*

ABSTRACT

Nano-emulsions are isotropic dispersed systems of two immiscible liquids, normally consisting of an oily system dispersed in an aqueous system, or an aqueous system dispersed in an oily system. The aim of this study was to formulate Nano-emulsion that is capable of penetrating the skin easily depending on its size or its homogeneity. Nano-emulsion was prepared using co-surfactants, Oleic acid as an oily phase, (Water) as an aqueous phase, Tween 20 as surfactant. The formulations were prepared, containing of (Vitamin A, Vitamin E, Lactic Acid, and Hydroquinone) to help in decreasing the signs and symptoms of skin dryness as emollient and bleaching agent of the skin. The formulations were characterized for zeta potential, particle size analysis. The results showed that the formulated nano-emulsions were of a uniform particle size of 178.9 ± 0.5 nm and with acceptable polydespersity index (PDI) value of 0.25 which indicate that the particle size distribution falls within a narrow range. The UV Spectrophotometric analysis showed red shift more than the plain formula, also scanning electron microscopy confirmed the spherecity of particles. We conclude that the nano-emulsion containing Vitamin A, Vitamin E, Lactic Acid, and Hydroquinone may serve as an emollient agent in many skin diseases e.g. age.

Keywords: Nano-emulsion, Transdermal delivery, Vitamin A, Vitamin E, Lactic Acid, and Hydroquinone.


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