RAMAN SPECTROSCOPY FOR PROCESS ANALYSIS & PROCESS ANALYTICAL TECHNOLOGY (PAT)
Omprakash G. Bhusnure*, Kailas G. Kale, Pentewar R.S, Gholve S.V, Nitin V. Gandage
ABSTRACT
Raman analysis is a technique that is gaining momentum in the realm of PAT applications. Raman, when applied propitiously, can lead to better process understanding, process optimization and process monitoring. Fiber optic coupling and the ability to do non-destructive analysis allows Raman to be used effectively for in-process monitoring. Raman provides the advantage of high spectral density leading to extensive chemical information. This means that diagnostic information concerning the molecular basis for process excursions is possible. Simple, straightforward quantitative calibrations can also be accomplished because of the potential for isolated diagnostic peaks. With the development of ATEX compliant Raman analyzers for liquid
phase primary application and large-spot analysis for solid-state analysis the instrumental barriers to routine Raman analysis in manufacturing have been overcome. It is the authors predication that since instrumental road-blocks to Raman acceptance have been removed the value of Raman as a PAT tool in all areas, from discovery to pharmaceutical manufacturing, will become more established.
Keywords: Raman analysis, In-process Monitoring, PAT applications.
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