Abstract

FORMULATION AND EVALUATION OF FLOATING ORAL INSITU GEL OF OFLOXACIN FOR STOMACH SPECIFIC DELIVERY

Arigela Bharathi*, Garikipati Priyanka, Vaida Aswini priya, Nadikatla Anusha, Sali Roja

ABSTRACT

Gastro retentive drug delivery systems have been widely used to prolong retention of dosage forms in stomach. Among the various approaches, the floating in situ gelling formulation offers sustained drug release as well as prolonged gastric retention, along with the added advantage of liquid oral dosage form. The present study was an attempt to formulate and evaluate floating in situ gel of Ofloxacin for eradication of Helicobacter Pylori (H.Pylori) which undergoes pH dependant sol-gel transition at gastric pH, there by prolonging the retention of the system in stomach. Sodium alginate a natural polymer was employed as a gelling agent where gelation is triggered by the source of calcium ions in the form of calcium carbonate. The evaluation was carried out for invitro parameters such as floating lag time, pH, gelling capacity, drug content and invitro drug release studies and the results substantiated that the optimized formulation revealed excellent floating characteristics and gastric retention.

Keywords: In situ gel, Ofloxacin, Sodium alginate, Calcium carbonate, pH dependant sol-gel transition, Sustained drug delivery.