Abstract

EFFECTS OF “CIRHEP10” ON BIOCHEMICAL PARAMETERS BASED ON SERUM AND HEART IN ALCOHOL INDUCED LIVER CIRRHOSIS

Jency Blesson*, Sibi Narayanan and V. G. Smitha

ABSTRACT

The aim of the study was to investigate the hepatoprotective activity of the polyherbal formulation on alcohol induced liver cirrhosis albino rats. The groups of animals were administered with CIRHEP10 at different doses. The effects of CIRHEP10 on preventing the changes in the metabolism of lipids in alcohol induced liver cirrhosis was investigated. Further, the drug was also studied for its effect of decreasing the concentration of cholesterol and triglycerides in serum and heart. The results demonstrated that CIRHEP10 significantly reduces the values in level of GOT, GPT and alkaline phosphatase. The treatment with drug decreases the level of total cholesterol, free fatty acid, TAG, ALP, AST and ALT activity very significantly. Thus it significantly reduced the deleterious effect caused by the administration of alcohol. The drug also showed significant increase in total protein content and A/G ratio. All our findings suggest that CIRHEP10 could protect the liver cells from alcohol induced liver damages.

Keywords: CIRHEP10, Liver cirrhosis, Serum, Heart, Alcohol.