Abstract

NATURAL ACID CATALYZED SYNTHESIS OF OCTAHYDROQUINAZOLINONE DERIVATIVES: A GREEN APPROACH

*Kirti S. Niralwad and Ishwar B. Ghorade

ABSTRACT

The Biginelli reaction is a multiple component reaction that gives 3,4-dihydropyrimidine-2(1H)-one which is widely used in pharmaceutical industries as calcium channel blockers1, antihypertensive agent, and alpha-1-a-antagonists. The reaction of aromatic aldehydes, dimedone and urea/thiourea using lemon juice as a natural catalyst under solvent-free conditions and microwave-irradiation gives excellent yield. This eco-friendly reaction has many advantages like economical, environmental, mild reaction conditions and simple work-up with high product yield. The research work concluded that the lemon juice is a naturally available, inexpensive and efficient catalyst for the synthesis of octahydroquinazolinone derivatives. The advantages offered by this method are solvent-free reaction conditions, short reaction times, ease of product isolation, and high yields. We believe that this method is a useful addition to the present methodology for the synthesis of octahydroquinazolinone derivatives.

Keywords: Biginelli reaction, Lemon juice, Microwave-irradiation, Natural acid and Octahydroquinazolinones derivatives.