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Abstract

STUDY OF ANTIBIOTIC SENSITIVITY AND RESISTANCE PATTERN IN SURGICAL PROCEDURES AND INCIDENCE OF POST OPERATIVE INFECTION – A PROSPECTIVE STUDY

Dr. Neelakanta Rao Paidi*, Dr. Koya Jagadish Babu, Dr. Kaveetha Devarajan, Rajeswari Ramaswamy, Dr. Sudarshan P.

ABSTRACT

Back ground: Surgical Site Infection (SSI) is a frequent cause of morbidity and mortality and adds significantly to the cost of care. These events represent the most common nosocomial infection in surgical patients. Microorganisms can get access into a wound either by direct contact of air borne dispersal or by contamination. The occurrence of infection and the increase in antibiotic resistance are two main factors in increasing the cost of the treatment at the hospital. The widespread use of antibiotics, together with the length of time over which they have been available have led to major problems of resistant organisms, contributing to morbidity and mortality. The main objective of the study is to find out the incidence of Post-operative infections in surgical cases and to evaluate the antibiotic resistance and sensitivity patterns of the micro organisms responsible for the post operative infection. Method: The subject’s case data were collected from the surgery department and Lab records. The collected data was analysed for the incidence of postoperative infection and the antibiotic sensitivity and resistance patterns. A prospective observational study is conducted for the period of 12 months in the department of general Surgery in the study hospital. Results: A total of 171 subjects who underwent clean contaminated and contaminated surgeries were included.Of the 171 cases, 35 cases found experience one or more symptoms of post operative infection. The Incidence of post operative infection was found to be 20%. The pathogens causing the post operative infection were found to be E.Coli, Klebiesella, Pseudomonas, Cocci, Staphylococcus Aureus, and MRSA. E.Coli exhibited more resistance to clindamycin and erythromycin (4%) and the sensitivity patters has shown that E.coli is more sensitive to amoxicillin (4%) and piparicillin- tazobactum(4%) followed by cloxacillin, norfloxacin, naldixic acid. The resistance pattern of klebiesella to the involved antibiotics meropenem, nitrofurantoin, vancomycin erythromycin, doxycycline etc and has shown maximum sensitivity to augmentin and cefixime (10%). Pseudomonas has shown maximum resistance to augmentin, ceftrixone, imepenem, erythromycin, doxycycline (11%) which can be comparable with the study carried out by and found to have equal sensitivity to piparacillim-tazobactum, ciprofloxacin, ofloxacin, amoxicillin, ampicillin, tetracycline (9%).Staph. Areus exhibited more resistance to ceftriaxone(9%) followed by amoxicillin(8%) and the sensitivity patterns were as follows with maximum sensitivity to cefoxitin, linezolid, augmentin, ofloxacin (7%). MSSA has shown maximum resistance to meropenem (20%) and equal range of sensitivity to cefixime, cefpodoxime, cefoxitin, chloramphenicol, cotrimoxazole, doxycycline, erythromycin, naladixic acid, imipenem, cefoxitin.The timely administration of antimicrobial prophylaxis in any surgical procedure may reduce the risk of post operative infection rate.

Keywords: Antimicrobial sensitivity and resistant patterns, surgical site infections, post-operative infections, timely administration.


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