Abstract

SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL ACTIVITIES OF 2-ARYL-3-[4/-PHENYL THIAZOLIDINYL]-4-OXO-THIAZOLIDINES

Meghasham N. Narule* and Karuna Baste

ABSTRACT

A novel series of 2-amino4-substituted phenyl thiazole (1a-i), 2-imine substituted phenyl-4-substituted phenyl thiazole (2a-i) 2-(4,-oxo-2 substituted aryl-Thiazolidinyl)-4/substituted phenyl thiazole. (3a-i) were prepared by the reaction of thiourea with different acetophone with excellent yield. Elemental analysis, IR, H1NMR, C13NMR & Mass spectral data established identification of the compounds (3a-i) was evaluated for their antimicrobial and antifungal activity.

Keywords: 4-oxo-thiazolidines, thioglycolic acid, spectral data, antibacterial activity, etc.