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Abstract

OCIMUM SANCTUM INHIBITS VASCULAR ENDOTHELIAL GROWTH FACTOR AND ANGIOGENESIS IN CHICK CHORIOALLANTOIC MEMBRANE

U. H. Shah*, G. R. Gonjari and A. E. Patil

ABSTRACT

Ocimum sanctum (Linn.) is the sacred herb. In India it is known as ‘Tulsi’ or ‘Holy Basil’. Every part of the plant is used in ethanomedicines to cure several pathological conditions. In this present investigation angiogenic efficiency of aqueous leaf extract of O. sanctum was studied by using chick chorioallantoic (CAM) assay. The CAMs were studied morphometrically, histologically and immunohistochemically. There was significant decrease in secondary and tertiary blood vessels at early hrs of treatment. The angiogenesis was inhibited more significantly at 72 and 96 hrs treatments. Decreased immunoperoxidase staining for VEGF indicated inhibition of VEGF synthesis by the extract. The antiangiogenic property of aqueous leaf extract of O. sanctum supports anticancerous ethanomedicinal property of this plant and paved the way to synthesize the new drug against tumor.

Keywords: Angiogenesis, Ocimum sanctum, CAM.


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