ACUTE AND SUBCHRONIC TOXICITIES OF ETHANOL EXTRACT HERB CRANBERRY (VACCINIUM MACROCARPUM L.) IN THE WHITE RAT WISTAR STRAIN
Resmi Mustarichie*, Sohadi Warya, Yoga Windhu Wardhana
ABSTRACT
Based on previous research, it has been reported that the methanol extract of the herb cranberry (Vaccinium macrocarpum L.) have anticancer activity as verified by the cell line MCF7 test. This paper reports on research support for the herb cranberry in the form of acute and subchronic toxicity tests of its ethanol extract. For the acute toxicity test done within approximately 14 days while the subchronic toxicity tests carried out for a period of 121 days. These tests using male and female white rats Wistar. Animals were randomly grouped into 5 groups of 5 mice each. The group given the test materials with different doses of a test group and a group of satellites, one group was
given a liquid carrier as a negative group. Fluid administration was done by oral route for 3 months. On day 91 the examination of hematology and blood chemistry. In the acute toxicity test values obtained LD50 the dose range of criteria was relatively safe because the LD50 was at doses higher than 15 g/kg body weight of mice, while for toxicity testing subchronic aims to look at the security level of the use of extracts of the long-term result with the conclusion that in order to use a period long ethanol extract of the herb cranberry with a dose of 500 mg/kg in female Wistar rats once a day did not cause toxic effects that vary for each organ.
Keywords: toxicity test, acute, subchronic, herb cranberry Vaccinium macrocarpum L.
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