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Abstract

EVALUATION OF ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF SECHIUM EDULE FRUITS IN ALLOXAN-INDUCED DIABETIC RATS

Sonali Maity1, Firdous SM1*, Debnath R1

1Department of Pharmacology, Calcutta Institute of Pharmaceutical Technology & AHS, Uluberia, Howrah: 711316, West Bengal, India.

ABSTRACT

The objective of this study was to investigate the effect of ethanolic extract of sechium edule fruits on alloxan induced diabetes in wistar rats. Oral administration of sechium edule (200 mg/kg, p.o. and 100mg/kg, p.o.) prevent the body weight loss and significantly (P<0.01) decrease the blood glucose level on 0, 7, 14, and 21 day. The lipid profile of diabetic rats was also improved on administration of ethanolic extract of sechium edule fruits.

Keywords: Sechium edule, diabetes, alloxan, lipid profile.


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