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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: APRIL ISSUE PUBLISHED

April Issue has been successfully launched on 1 April 2024.

Abstract

METHOD DEVELOPMENT AND VALIDATION OF CEFPODOXIME PROXETIL IN IMMEDIATE RELEASE DOSAGE FORM BY USING RP-HPLC

N.Gopi*, D.Narasimha Rao¹, M.Prasad Rao¹, Sivashankar.R.Beeravalli²

¹Department of Pharmaceutical Analysis, M.A.M College of Pharmacy, Kesanupalli, Narasaraopet,Guntur-522601
²inkwood Drive, Fredericks Burg, Virginia-22407.

ABSTRACT

A simple, sensitive and rapid reverse phase high performance liquidchromatographic method was developed for the estimation ofCefpodoxime proxetil in pure and in pharmaceutical dosage form. AHypersil BDS C18 (250 x 100 mm, 4.5m) was used with a mobilephase containing a mixture of and Potassium dihydrogen phosphateand Acetonitrile buffer adjusted to Ph6.5+ 0.1 with PotassiumHydroxide in the ratio of 62:38. The flow rate was 2.0ml/min andeffluent was monitored at 235nm and peaks eluted at 7.7min, 8.7min.Calibration curve was plotted with a range from 17.5-87.51 μg/ml. Theassay was validated for the parameters like linearity, precision,accuracy, robustness and system suitability parameters. The proposedmethod can be useful in the routine analysis for the estimation ofCefpodoxime Proxetil in pharmaceutical dosage form.

Keywords: Cefpodoxime Proxetil, RP-HPLC.

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