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Abstract

BIOTRANSFORMATION OF 4-ANDROSTENE-3, 17-DIONE TO ANDROST-1, 4-DIENE-3, 17-DIONE BY NOCARDIOIDES SIMPLEX

Umesh Luthra*, Sneha Khadpekar, Aditi Trivedi, Apoorva Shetty, Harish Kumar

ABSTRACT

Microbial dehydrogenation is one of the most important transformations in the synthesis of steroid hormones. The current study focuses on biotransformation of 4-androstene-3, 17-dione (AD) to androst-1, 4-diene-3, 17-dione (ADD) using Nocardioides simplex. It is one step reaction catalyzed by the enzyme 3 - ketosteroid - delta 1 - dehydrogenase, which is produced by N. simplex. The key physicochemical factors involved in the biotransformation were analyzed in details. Factors such as components of buffer, inducer, substrate, temperature, pH, cell mass and types of cyclodextrins were taken into consideration in this study.

Keywords: Nocardioides simplex, Biotransformation, androst-1, 4-diene-3, 17-dione, 4-androstene-3, 17-dione.


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