SYNTHESIS, WOUND HEALING AND DIURETIC ACTIVITY OF SOME NEW 1, 3, 4 THIADIAZOLE DERIVATIVES
Rumpa Banerjee, D. Roy and Dr. Mrityunjoy Banerjee
ABSTRACT
Six substituted N-aryl,5-substituted phenyl 1,3,4-thiadiazole(7a-f) were synthesized by the reaction of different substituted benzaldehyde with different substituted 5-phenyl 1,3,4-thiadiazole 2-amino in the presence of sulphuric acid in refluxing methanol. The newly synthesized compounds were characterized by spectroscopic methods. Further, the synthesized compounds were screened for Toxicity study, Wound healing activity and Diuretic activity by standard method. Results of the activities reveal that some compounds exhibited less toxicity and moderate to good Wound healing and Diuretic activity.
Keywords: Six substituted N-aryl,5-substituted phenyl 1,3,4-thiadiazole(7a-f)
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