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Abstract

FORMULATION AND EVALUATION OF NIFEDIPINE FLOATING TABLETS AS GASTRORETENTIVE DRUG DELIVERY USING A COMBINATION OF POLYMERS

T. Mangilal*, P. Shashikala and K. S. K Rao Patnaik

ABSTRACT

Gastro retentive dosage form using Guar gum was prepared to develop a floating tablets of Nifedipine that could retain in the stomach for longer periods of time delivering the drug to the site of action, i.e., Stomach. The pre-compression parameters of all formulations showed good flow properties and these can be used in tablet manufacture. The post-compression parameters of all formulations were determined and the values were found to be satisfactory. From the drug content and in-vitro dissolution studies of the formulations, it was concluded that the formulation F5 i.e. the formulation containing Guargum, PVP, Sodium bicarbonate, micro crystalline cellulose and Magnesium stearate is the best formulation.As a result of this study, it may be concluded that the floating tablets using a guar gum in optimized concentration can be used to increase the GRT of the dissolution fluid in the stomach to deliver the drug in a controlled manner. The concept of formulating floating tablets of Nifedipine offers a suitable and practical approach in serving desired objectives of gastro retentive floating tablets.

Keywords: Nifedipine, HPMC, Floating tablets. Direct Compression, In vitro Dissolution, Ethyl cellulose, controlled release.


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