Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS OCTOBER ISSUE PUBLISHED
  • OCTOBER 2020 Issue has been successfully launched on 1 October 2020.

Abstract

IN SILICO DOCKING STUDIES ON CYCLOOXYGENASE 2 INHIBITORS IN THE TREATMENT OF COLORECTAL CANCER

P. R. Kiresee Saghana* and S. Hemalatha.

ABSTRACT

Colorectal cancer is a malignant tumor arising from the inner wall of the large intestine. Deaths from cancer worldwide are projected to continue rising, with an estimated 12 million deaths in 2030. Colorectal cancer is one of the main types of cancer causing overall cancer mortality each year. COX-2 is not detectible in most normal tissues, but is induced by proinflammatory cytokines, growth factors and carcinogens, implying a role for COX-2 in both inflammation and control of cell growth. COX-2 plays a very imperative role in colorectal cancer. Considering the side effects of the anticancer drugs, the present study was undertaken to substantiate the inhibition potential of the receptor protein COX-2. 4-hydroxypropiophenone(4-HPPP) are analysed and optimized to investigate the interactions between the target compound and the amino acid residues of the COX- 2 protein. Docking studies have been carried out in the active site of COX-2 by using Discover Studio Version 4.5 (Biovia Dassault System, USA). Ligand was docked with target receptor.The energy values were denotes in Lib Dock score 69.8557KDa.

Keywords: Colorectal cancer, cyclooxygenase-2, 4-hydroxypropiophenone, Docking and Discovery Studio.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More