Abstract

DESIGN, OPTIMIZATION AND CHARACTERIZATION OF PH SENSITIVE NANOPARTICLES OF DULOXETINE HYDROCHLORIDE FOR ENHANCEMENT OF ORAL BIOAVAILABILITY

Kumar Sandeep*, Rani Deepika and Setia Anupama

ABSTRACT

The aim of the study was to develop pH sensitive nanoparticles of duloxetine hydrochloride for increasing the oral bioavailability. Depression is a mental disorder that affects millions of people worldwide. The conventional drugs available for its treatment have less bioavailability hence such a system is needed which protects the drug in adverse conditions, enhances the oral bioavailability and also provide sustained drug release to reduce frequent dosing. Duloxetine hydrochloride was the drug of choice and was incorporated into nanoparticles by controlled precipitation method. To deliver drugs at predetermined rate for fixed time period, pH sensitive drug delivery system was prepared to deliver the drug orally. The prepared nanoparticulate formulation was made pH sensitive by using Eudragit L100 to increases the stability of drugs in gastric fluids and to release the drug in the intestinal pH by the dissolution of the polymer in a pH and time controlled manner. The formulation was characterized for particle size, shape, entrapment efficiency, in vitro drug release. Prepared nanoparticle formulation showed enhanced bioavailability and pH sensitive drug release in the intestine.

Keywords: Duloxetine HCl, pH Sensitive, Nanoparticles, Eudragit L100.