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Abstract

INVITRO ANTICANCER ACTIVITY OF CURCUMA LONGA AGAINST HUMAN BREAST CANCER CELL LINE MCF-7

Prasanthi Donipati* and Dr. S. Hara Sreeramulu

ABSTRACT

Turmeric (Curcumo longa) commonly known as Halad in Marathi and Haldi in Hindi is an Indian spice and medicinal plant belonging to Zingiberaceae family and is expensively used in Ayurveda, Unani and Siddha medicine as home remedy for various diseases. Breast cancer is a significant cause of death among women worldwide. The purpose of this study is to test in vitro anticancer activities of the hexane, chloroform and methanolic extracts of Curcuma longa against the human breast cancer cell lines [MCF-7]. The Average values of (Hexane, Chloroform and Methanolic concerntrations) of Curcuma longa were shown in (Table 1), Out of which Chloroform Average values was found to be more 10:62.9, 20:32.1, 40:3.0,80:31.5) than Hexane and Methanolic concerntrations.Agraph was plotted between different concentrations of Curcuma longa (Hexane, Chloroform and Methanolic concerntrations) had different cytotoxicity effects on MCF7 cell line (Figure 1). The plant extract investigated in this study have significant anticancer activity against the breast cancer cell lines tested. Further investigation is required to isolate and elucidate the structure of the compounds responsible for the observed activity.

Keywords: Curcumo longa, breast cancer, anticancer activity, hexane, chloroform and methanolic.


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