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K. Bhargavi, S. Indira* and Prathima Srinivas


The aim of present work was to formulate and evaluate cubosomes of Aceclofenac a Non -steroidal anti -inflammatory drug (NSAID), as cubosomal oral capsules to reduce gastric irritation because cubosomal dispersions are thermodynamically stable and bio compatible in nature and to sustain the release of drug. Different formulations of Aceclofenac cubosomes were prepared by Top down approach using GMO as lipid phase vehicle, Poloxamer 407 as stabilizer and distilled water as aqueous phase by varying the concentrations of GMO and Poloxamer 407.Resultant formulations were characterized for particle size, zeta potential, surface morphology, encapsulation efficiency and in-vitro drug release. Optimized formulation (F10) showed drug release of 83.25% in 8hours.Aceclofenac cubosomal oral capsules were prepared with optimized cubosomal formulation to which starch and aerosol were added as adsorbing agents to obtain a wet mass. Then the wet mass was passed through sieve no.16 to form granules. Then the granules were air dried for 24 hrs. The dried granules were filled into capsules. The granules were evaluated for flow properties, drug content and invitro drug release.Optimized capsule formulation (C3) a highest entrapment efficiency of 97.8% and drug release of 71.9% in 8 hours. Invitro release kinetics followed zero order release.

Keywords: Cubosomes, Aceclofenac, Oral Capsules, GMO, Starch, Top down approach.

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