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Abstract

NEURO PROTECTIVE EFFICACY OF PHYTOTHERAPEUTIC METHANOLIC EXTRACT OF POLYHERBAL (TRIPHALA) ON IMIDACLOPRID INDUCED TOXICITY IN WISTAR RATS

V. Eugin Amala*, Dr. M. Jeyaraj, M. Meldintha Mary

ABSTRACT

Human population continues the possibility of developing neurodegenerative diseases. Two important factors contributing to degenerative brain diseases are oxidative stress and inflammation. Acetylcholine esterase (EC 3.1.1.7) is an enzyme, actively involved in cleaving the ester bond found in the molecule acetylcholine (a neurotransmitter). The enzyme plays an important role in detecting a wide array of neurodegenerative disorders like Parkinson’s disease, Alzheimer’s disease and Huntington’s disorders. Fruits of Terminalia chebula, Terminalia bellirica, Phyllanthus emblica are compositions of traditional preparation known as polyherbal drug Triphala which is commonly prescribed by many traditional healthcare practitioners. It is an important healthcare tonic for detoxification, rejuvenation, anti-inflammation and anti-ulcer. In order to elucidate their health related benefits, the neuroprotective and anti-inflammatory effects of methanol extract of fruits were investigated. In addition, underlying mechanisms of the neuroprotective effect and histopathological activities were revealed. The results from the present study not only support traditional uses of the polyherbal formulation Triphala but also provide benefits in treatment and prevention of neurodegenerative diseases or other disorders which oxidative stress and inflammation is implicated.

Keywords: Triphala, Terminalia chebula, Terminalia bellirica, Phyllanthus emblica, Imidacloprid (IMI), nAChRs.


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