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Abstract

AMELIORATIVE EFECTS OF POLYGONUM BISTORTA AND ZINGIBER ROSEUM ON CARBON TETRACHLORIDE TREATED RATS

Deepak Kumar Mittal1*, Alok Kumar Jena2 and Deepmala Joshi1

1School of Studies in Zoology, Jiwaji University, Gwalior - 474011 (MP), India.
2CBT, Siksha `O` Anusandhan University, Bhubaneswar, Odisha. India.

ABSTRACT

The present study was carried out to observe the hepatoprotective effect and antioxidant activity of the aqueous extract of the roots of Polygonum bistorta (PB) (200 mg/kg) and Zingiber roseum (ZR) (250 mg/kg) in rats treated with carbon tetrachloride (0.15 ml/kg, i.p.). Extract of PB and ZR at the tested doses restored the levels of liver homogenate enzymes (glutathione peroxidase, glutathione-Stransferase, superoxide dismutase and catalase enzymes significantly. The activities of MTT assay significantly recovered the damage towards normal, and supported the biochemical observations. This study suggests that Zingiber roseum has a more liver protective effect in comparison of Polygonum bistorta and against carbon tetrachlorideinduced hepatotoxicity and possess antioxidant activities and extracts exhibited moderate anticancer activity towards cell viability at higher concentration.

Keywords: Polygonum bistorta; Zingiber roseum; Hepatoprotective effect; Carbon tetrachloride; Anti cancerous.


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