Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS OCTOBER ISSUE PUBLISHED
  • OCTOBER 2020 Issue has been successfully launched on 1 October 2020.

Abstract

SYNTHESIS OF SCHIFF’S BASE DERIVATIVES OF OXAZINE FROM CHALCONES AND EVALUATION OF THEIR ANTIBACTERIAL ACTIVITY

P. Anusha*, P. Manichandrika, S. Shruthi, Syeda Uzma Nishat, Sumaiyya Sultana

ABSTRACT

Chalcone is a generic term given to compounds bearing the 1, 3-diphenyl-2-propen-1-one framework. Chalcones are the bichromophoric molecules separated by a keto-vinyl chain and belong to the flavonoid family. Oxazine heterocycles have special interest because they constitute an important class of natural and non natural products and show useful biological activities. Its increasing importance in pharmaceutical and biological field, we are planned to synthesize oxazine derivatives for their biological activities. A considerable amount of research activity is directed towards a potent, more specific and less toxic compounds. We planned to synthesize Schiff base oxazine derivatives from chalcones and evaluate for antibacterial activity. The synthesized compounds were confirmed structurally by means of IR, 1HNMR, Mass spectral analysis. Further, the synthesized compounds (5a1, 5a2, 5a3, 5a4, 5a5, 5b1, 5b2, 5b3, 5b4, 5b5) were screened for anti bacterial activity at the concentration of 50g/ml and 100g/ml using DMF as a control against the organism’s Bacillus Pumilus, Bacillus subtilis, Staphylococcus aureus, Eschertia coli and Pseudomonas aeruginosa by disc diffusion method on nutrient agar media. The standard drug used was Ampicillin for the comparison at the concentration 50g/ml and 100g/ml against all the above mentioned organisms. Results indicates that compounds 5b4, 5b5 and found to posess good antibacterial activity against the organisms. Eschertia coli and Pseudomonas aeruginosa at 100g/ml concentration. Whereas the compound 5b2 was found posses good antibacterial activity against all the tested organisms, which is equipotent to the standard drug Ampicilline.

Keywords: Antimicrobial activity, Chalcones, IR, 1HNMR, Mass spectroscopy, Oxazine.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More