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Abstract

FORMULATION AND EVALUATION OF THERMOSENSTIVE OCULAR INSITU GELS FOR SUSTAINED RELEASE OF BALOFLOXACIN

P. J. Prasuna Sundari*, Rasagna Maddela and Dr. Prathima Srinivas

ABSTRACT

The aim of the present study was to formulate and evaluate ophthalmic drug delivery system of Balofloxacin based on the concept of thermo-sensitive gelation. Balofloxacin is a fourth generation broad spectrum fluoroquinolone antibiotic indicated for infective ophthalmitis. Insitu gel was formulated by cold method using different concentrations of Poloxamer and Chitosan as thermoreversible polymers. Prepared formulations were evaluated for gelling capacity, drug content, rheological studies, gelation time, gelation temperature, in-vitro diffusion studies and antimicrobial activity. The pH of all the formulations was found to be 7.4. Formulation (G7) was optimized based on drug content and in vitro drug release studies. All the formulations were found to be clear and devoid of particulate matter. With the increase in concentration viscosity of the solution increases which renders sustained release of the drug from the formulation over a period of 10h. Gelling capacity studies revealed that G7 showed good gelation characteristics. The results of in-vitro drug release studies indicated that with the increase in the polymer concentration the more was the sustained delivery of drug. The zone of inhibition for both Staphylococcus aureus and E.coli was found to be significantly greater for tested formulation than the pure API. Stability studies concluded that the developed systems were stable for 3 months. Hence thermosensitve insitu gels were concluded to be a suitable approach by improving the bioavailability and thereby increases the precorneal residence time.

Keywords: Insitu gelling system, thermosensitive, Balofloxacin, antimicrobial studies.


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