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Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF OFLOXACIN IN-SITU OPHTHALMIC GEL

S. B. Gondkar*, Pallavi R. Kute and R. B. Saudagar

ABSTRACT

Ofloxacin is a fluorinated 4-quinolone antibiotic which is used in the treatment of ophthalmic ailments like infections, inflammations, conjunctivitis, blepharitis, iritis, corneal ulcer etc. Commercially, ofloxacin eye drop solution is available and it is quite easy for the administration. However, the product has drawback of poor bioavailability due to several factors such as tear production, non-productive absorption, transient residence time, and impermeability of corneal epithelium. In order to improve the bioavailability, residence time and longer duration of action, an attempt was made to formulate in-situ ophthalmic gel of Ofloxacin. In present study Carbopol 934 and Sodium alginate were used as polymers. Carbopol 934 was used as a pH sensitive polymer and Sodium alginate was used as mucoadhesive polymer. All 9 prepared formulations were optimized by 32 factorial design. The prepared formulations were evaluated for pH, clarity, viscosity, drug content, gel strength, bioadhesive strength, in vitro drug release, antibacterial activity, isotonicity test, ocular irritancy test and stability.

Keywords: Ofloxacin, Carbopol 934, Sodium alginate, in-vitro drug release, antibacterial activity.


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