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Abstract

BIOCHEMICAL STUDY ON ENZYMATIC ANTIOXIDANT IN ASTHMATICS

A. G. Rajalakshmi*

ABSTRACT

Oxidative stress contributes to the pathophysiology of respiratory disorders and other chronic diseases associated with asthma. Increased levels of oxidants are considered a marker of the inflammatory process. The objective of the present study was to investigate the levels of antioxidants status in asthmatic patients in comparison with healthy volunteers. Lipid peroxidation assay, Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx), Catalase (CAT), was determined in 95 asthmatic patients based on severity. The results of the present study suggest that downward and elevated level of antioxidants are associated with the severity of asthma, The results revealed the existence of an increased oxidative stress and reactive oxygen species in asthmatics, with altered antioxidant capacities.

Keywords: MDA, SOD, GPx, CAT, Asthma.


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