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Abstract

OPIOIDS: THE PRACTITIONER’S EFFICACIOUS PAIN ANALGESIC AND MANAGEMENT OF ITS ADVERSE EFFECTS ON THE GUT

*Niraj Khatri Sapkota and Kailash Chandra Swain

ABSTRACT

Opioids are very effective analgesic agents being extensively prescribed globally by the clinicians in their day to day practice for the alleviation of pain of the patients. Although, it is one of the most potent pain reliever. The draw back is that such unique therapeutic benefit of opioids is always accompanied by unacceptable gastrointestinal adverse effect i. e. constipation.Now, in the present context, the long-term administration of an opioid for the treatment of chronic noncancer pain continues to be questionable & controversial. No doubt,concerns related to the effectiveness, safety, and abuse liability have evolved over decades, but still clinicians in general are willing to endorse such therapy. For the managements of opioids induced gastrointestinal disorder, the present review would like to emphasize here first on some non-pharmacological basis of treatments [ drugless ] which will certainly benefit opioids induced constipation as well as constipation in general followed by some adjunctive drugs for the management of such gastrointestinal event.

Keywords: Oipoid, pain, therapeutics, gut functions.


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