Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.

Abstract

IN VITRO STUDIES ON INTERACTIONS BETWEEN CT-DNA AND NP- CHLOROPHENYL-2-FUROHYDROXAMIC ACID

Shakuntla Raj, Deepesh Khare and Rama Pande*

School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur, 492010, Chhattisgarh, INDIA.

ABSTRACT

The interaction of N-p-Chlorophenyl-2-Furohydroxamic Acid, (NCFHA) with calf thymus DNA (Ct-DNA) has been studied using absorption and emission spectroscopy, viscosity and docking. The results revealed decrease in absorption spectra, fluorescence quenching and enhancement of viscosity upon binding affinity to Ct-DNA. The binding constant Kb determined by absorption measurements for NCFHA- DNA complex was found to be 2.38 x 104 M-1 and Stern Volmer constant of complex is obtained as 8.94 x 102 M-1. The increase in viscosity and melting temperature (Tm) of DNA shows its interaction with the molecule. Docking was done using rigid modes of N-CFHA through Hex software package. The nature of binding and binding strength between N-CFHA and DNA is obtained from docking. Both experimental results and docking studies indicate the binding nature of N-CFHA bind with DNA.

Keywords: DNA–drug interactions, Hydroxamic acids, Viscosity, Fluorescence, UV.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More